During the past years we have carried out experiments in very high time and space resolution in Astronomy by means of novel utilizations of the properties of light. Regarding time, we have conceived a photometer capable to time tag the arrival time of each photon with a resolution and accuracy of few hundred picoseconds, for hours of continuous acquisition and with a dynamic range of more than 6 orders of magnitude. The final goal is a "quantum" photometer for the E-ELT capable to detect and measure second order correlation effects (according to Glauber description of the EM field) in the photon stream from celestial sources. Two prototype units have been built and operated, one for the Asiago 1.8m telescope and on for the 3.5m NTT. Results obtained on optical pulsars will be presented. Among the second order effects, Hanbury Brown Twiss Intensity Interferometry has been already successfully tested at the NTT, giving hopes to perform very high spatial resolution observations among telescopes not optically linked, e.g. the E-ELT at Cerro Armazones and the VLT at Cerro Paranal, or Cerenkov light telescopes such as Magic or CTA. A second avenue for high space resolution is being explored using the Orbital Angular Momentum of the light beam and associated Optical Vorticity. The classical Rayleigh criterion of resolution can be ameliorated by an order of magnitude. Promising tests have been made with a coronagraph at the 122cm telescope in Asiago. Extension to the radio domain is now under way.