I will first review the status of Dark Matter searches, with particular attention to indirect searches with gamma-ray and neutrino detectors. I will then discuss the recent observations of the Galactic center with Air Cherenkov Telescopes, in particualr HESS, and their implications on the nature and distribution of Dark Matter. Finally, I will introduce a new class of objects, Intermediate Mass Black Holes, and argue that they may provide a new and unique signature of Dark Matter annihilations, making detailed predictions for the gamma-ray satellite GLAST, scheduled to be launched in 2007.