The ESO Large Programme "First Stars", coordinated by Roger Cayrel,
is providing detailed chemical abundances for the most metal-poor stars
found in the Galaxy. In this talk I will review our main results
concentrating on the  latest results on the CNO elements, the carbon
isotopic ratios and lithium.
I will also illustrate some of the  results on the CEMP (Carbon Enhanced
Metal Poor) stars, which display considerable complexity which is a
serious challenge to our understanding of these stars.
I will also briefly review the research carried out by the CIFIST team
and our ideas on what can and should be done beyond the "First Stars"
programme.