Horizontal branch stars are low-mass stars that burn helium in their cores and hydrogen in a shell surrounding those cores. They play an important role in a variety of astrophysical contexts, ranging from our understanding of the interplay between stellar pulsation and evolution to the formation history of globular clusters and, indeed, galaxies as a whole. They are also sensitive probes of some key parameters of particle physics that are poorly constrained by laboratory experiments. In this talk, I shall discuss several different problems in which horizontal branch stars do indeed play an important role, including the early formation history of the Milky Way and the possibility of multiple populations with widely varying levels of helium enhancement being present in globular clusters.