The observed acceleration of the cosmic expansion represents one of the most intriguing open problems of modern Physics. Although observationally consistent with the effects of a cosmological constant, its fundamental nature might reside in more complex physical mechanisms like a slowly evolving light field or a modification of the laws of gravity at large scales. From an observational point of view, however, it is often extremely difficult to distinguish these different possible Dark Energy models from the standard cosmological constant if only background and linear observables are used. In this context, the nonlinear regime of structure formation - directly testable by means of large numerical simulations - offers the possibility to break such degeneracy by highlighting possible characteristic observational footprints of different competing Dark Energy scenarios. In this talk, I will provide a general overview of the field of Dark Energy simulations, from the simplest case of homogeneous Quintessence to the more complex case of inhomogeneous and interacting Dark Energy and Modified Gravity simulations. I will then present some specific examples of Dark Energy models that evade all background and linear perturbations tests and that could be possibly identified only through nonlinear observables. Finally, I will discuss how these different numerical approaches will be refined and systematically employed in the near future to drive observational efforts in the field of Dark Energy investigations, with a particular focus on the planned simulations program of the Euclid collaboration.