The chemical evolution of the Milky Way will be discussed: in particular, recent and accurate stellar and nebular abundance data will be compared with detailed chemical evolution models to infer important constraints on nucleosynthesis and mechanisms of galaxy formation. We will discuss the abundances of heavy elements such as C, N, O, alpha-elements, Fe, Fe-peak elements as well as s- and r- process elements.From abundance ratios in the solar vicinity we can infer the timescales for the formation of the inner halo (no longer than 2 Gyr) and the local disk (6-8 Gyr), while from abundance gradients we can infer that the disk formed inside-out. We will show some new data and models also for the Galactic bulge and conclude that the Bulge formed very quickly (0.1-0.5 Gyr) during a strong starburst. Finally, we will present models for the chemical evolution of the dwarf spheroidals (dSphs) of the Local Group, showing how their [X/Fe] versus [Fe/H] relations are different from those of the Milky Way. In particular, we will show that the abundances in the dSphs require a slow star formation rate coupled with very efficient gas removal (winds), leading to the conclusion that these dwarfs are not likely to be the building blocks of our Galaxy.