Compton scattering of the CMB by electrons in clusters of galaxies imprints on the radiation a signature - the Sunyaev-Zeldovich effect - whose spectral and spatial characteristics constitute indispensable cosmological probes. The effect, essentially a redshift-independent CMB image of a cluster, has been measured in many clusters by single dish and interferometric arrays. Current and near-future measurement capability, accurate theoretical description, and realistic modeling of intracluster gas, have significantly advanced use of the effect as a precise diagnostic tool to determine cluster and cosmological parameters. I will describe the effect and the spatial CMB anisotropy it induces, and will review the main results from current measurements.